Hydrogels：HAMC hydrogel–PLGA–carboxylate NPs
| 【Numbering】BKMB100010 | 【CAS】CAS | ||
| 【Item No.】BKMB100010-2 | 【specification】 | ||
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Name: HAMC hydrogel PLGA carboxylate NPs
Composition: PACAP, HA, MC, and PLGA
Size: 200-400 nm
Application: for the treatment of central nervous system diseases
Storage conditions: -4℃
Other instructions: Half a year shelf under sealed state [Main Advantage] 37 C, PLGA body degradation causes the accumulation of hydroxyacetic acid, lactic acid monomer and oligomers, resulting in acidic local pH value, neutralizing the surface charge of PLGA and promoting the release of PACAP. As PLGA is gradually hydrolytically degraded by PLGA, the pore structure formed on its surface will promote water penetration, and the production of acidic degradation by-products will autocatalytic degradation of PLGA, the pH around PLGA continues to decrease, the carboxylate anion protonated carboxylic acid, less electrostatic interactions, and PACAP desorption and faster release from the complex.
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Composition: PACAP, HA, MC, and PLGA
Size: 200-400 nm
Application: for the treatment of central nervous system diseases
Storage conditions: -4℃
Other instructions: Half a year shelf under sealed state [Main Advantage] 37 C, PLGA body degradation causes the accumulation of hydroxyacetic acid, lactic acid monomer and oligomers, resulting in acidic local pH value, neutralizing the surface charge of PLGA and promoting the release of PACAP. As PLGA is gradually hydrolytically degraded by PLGA, the pore structure formed on its surface will promote water penetration, and the production of acidic degradation by-products will autocatalytic degradation of PLGA, the pH around PLGA continues to decrease, the carboxylate anion protonated carboxylic acid, less electrostatic interactions, and PACAP desorption and faster release from the complex.
Title:Tunable Surface Charge Enables the Electrostatic Adsorption-Controlled Release of Neuroprotective Peptides from a Hydrogel–Nanoparticle Drug Delivery System
Article link:https://doi.org/10.1021/acsami.2c17631
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