納米SiO2
| 【Numbering】BKMC105001 | 【CAS】CAS | ||
| 【Item No.】BKMC105001-2 | 【specification】 | ||
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Name: Nano-SiO2
Composition: SiO2
Grain size: ~100nm
Application: Molecular mechanism of autophagy dysfunction in hepatocytes
Storage conditions: -4℃
Other instructions: sealed state shelf life for half a year [main advantage] nano SiO2 through ROS induced ER stress, activate EIF2AK3 (PERK) and ATF 6 signaling pathway, upregulate downstream transcription factor ATF 4 and DDIT 3 (CHOP), thus promote autophagy gene ATG 12 and LC3B transcription, enhance autophagosome synthesis, and aggravate the autophagosome accumulation, cause autophagy dysfunction, toxicity to cells.
Message
Composition: SiO2
Grain size: ~100nm
Application: Molecular mechanism of autophagy dysfunction in hepatocytes
Storage conditions: -4℃
Other instructions: sealed state shelf life for half a year [main advantage] nano SiO2 through ROS induced ER stress, activate EIF2AK3 (PERK) and ATF 6 signaling pathway, upregulate downstream transcription factor ATF 4 and DDIT 3 (CHOP), thus promote autophagy gene ATG 12 and LC3B transcription, enhance autophagosome synthesis, and aggravate the autophagosome accumulation, cause autophagy dysfunction, toxicity to cells.
Title:Silica nanoparticles induce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPR pathways in hepatocytes
Article link:https://news.ccmu.edu.cn/syyw_12977/95626.htm
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance.The website pictures are from the Internet. The pictures are for reference only. Please take the real object as the standard. In case of infringement, please contact us to delete them immediately. |
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