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The use of functional materials to prepare stimulus-responsive nano-medicine particles, such as isopropylacrylamide (PNIPAAm) is often used as a substrate for temperature-sensitive carriers, so that it can achieve unique biological characteristics (temperature) differences in the disease source area and realize Delivery of drugs. Service design particles: liposomes, micelles, gels, complexes, etc.; response form: temperature, pH; drug factor: chemotherapeutic drugs; service content: design prescription conditions, optimize preparation processes, sample verification; physical and chemical indicators: The particle size index is 100-200nm, the release is stable, and the stability is 1-6 months.