Biological hybrid microrobots
Biohybrid microrobots, which integrates magnetic, thermal and hypoxia sensitivity and an internal fluorescent protein as a dual reporter gene for both thermal and localization signals for targeted cancer therapy.
The microrobot system has three key elements, including magnetic nanoparticles (MNP) loading probiotic neg 1917 (EcN @ MNP) spatial magnetic and hypoxia sensing, thermal logic circuit designed to bacteria control mCherry biosynthetic temperature and localization reporter, and NDH-2 enzyme-encoded enhanced anticancer therapy. Based on fluorescent protein-based imaging feedback, the microrobot showed good thermal sensitivity and active targeting to the tumor region
Reference Documentation：https://doi.org/10.1021/acsnano.1c11601
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